Replication of molluscum contagiosum virus.
Replication of molluscum contagiosum virus.
复制标题
传染性软疣病毒的复制。
DOI：
10.1006/viro.1995.0037
复制
发表时间：
1995
期刊：
影响因子：
3.7
通讯作者：
Kreider,J
中科院分区：
文献类型：
--
作者：
Buller,RM;Burnett,J;Chen,W;Kreider,J
传染性软疣病毒（MCV）感染青春期前的儿童和性活跃的成人，经常导致一个毁容的皮肤疾病，免疫抑制的艾滋病毒感染的个人。由于未能在实验室中复制病毒，有效治疗方案的开发受到阻碍。在这里，我们报告的MCV复制在实验系统中的第一个演示。在人类包皮移植到无胸腺小鼠，MCV诱导的形态学变化是无法区分的患者活检，包括发展和迁移的软疣体含有成熟的病毒粒子的表皮表面。
Molluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals. The development of an efficacious treatment regime has been hampered by the failure to replicate the virus in the laboratory. Here we report the first demonstration of MCV replication in an experimental system. In human foreskin grafts to athymic mice, MCV induced morphological changes which were indistinguishable from patient biopsies and included the development and migration of molluscum bodies containing mature virions to the epidermal surface.