An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles
An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles
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DOI：
10.1021/jo1011174
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发表时间：
2010-08-06
影响因子：
3.6
通讯作者：
Browne, Duncan L.
中科院分区：
文献类型：
--
作者：
Crossley, James A.;Browne, Duncan L.
报道了亚硝酸根和亚硝酸根之间的热促进环加成反应。该方法具有很好的区域选择性，对碘代炔和氯仿都有很大的应用范围。通过铃木交叉偶联可以实现高度修饰的碘异恶唑基元的进一步功能化。
The thermally promoted cycloaddition between alkynyliodides and nitrite oxides is reported. The process offers excellent regioselectivity and a broad scope with respect to both the iodoalkynes and chloro-oximes. Further functionalization of the highly decorated iodoisoxazole motifs can be achieved via Suzuki cross-coupling.