Three generations of α,γ-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes
Three generations of α,γ-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes
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DOI：
10.1016/j.jbbm.2006.02.006
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发表时间：
2006-11-30
影响因子：
--
通讯作者：
Kokotos, G.
中科院分区：
文献类型：
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作者：
Bellis, E.;Hajba, L.;Kokotos, G.
将含有4，8，16个自由氨基的三代α，γ-二氨基丁酸修饰的聚丙亚胺树枝状大分子[DAB(AM)(N)，n=4，8，16]与Boc保护的α，γ-二氨基丁酸(DABA)部分高产率偶联。对修饰后的树枝状大分子进行了脱保护处理，得到了表面含有8、16和32个氨基的手性树枝状胺，产率较高。游离胺类树枝状大分子与四氯铂酸钾(II)反应生成了周边带有顺铂结构的树枝状大分子。通过红外光谱、热重分析和元素分析等手段对其进行了表征。(C)2006爱思唯尔B.V.保留所有权利。
Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)(n), n=4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis. (c) 2006 Elsevier B.V. All rights reserved.