CATALYTIC ASYMMETRIC C-C BOND FORMATION - NEW ENOLATOLITHIUM AND ORGANOLITHIUM CHEMISTRY
CATALYTIC ASYMMETRIC C-C BOND FORMATION - NEW ENOLATOLITHIUM AND ORGANOLITHIUM CHEMISTRY
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DOI：
10.1002/anie.199501781
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发表时间：
1995-02-03
期刊：
影响因子：
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通讯作者：
BERRISFORD, DJ
中科院分区：
文献类型：
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作者：
BERRISFORD, DJ
有机锂试剂是现代有机化学发展和实践的基石。这些试剂的关键作用反映了它们在本科化学课程中的早期引入。尽管人们对催化不对称CC键的形成产生了巨大的兴趣。21在其他领域提供了一些实用的解决方案，对映体选择性很高，有机锂试剂的催化反应一般仍然难以捉摸。锂离子所特有的复杂溶液平衡，不断地挫败了发现可行催化过程的尝试。最近的两项工作[4]朝着这一目标取得了有价值的进展。Koga等人。已发现[41]硅烯醇醚1和3衍生的锂烯醇酸盐的不对称苄基化反应的显著催化过程(方案1)。在此之前，刻板控制
Organolithium reagents are a cornerstone of the development and practice of modern organic chemistry. The pivotal role of these reagents reflects their early introduction in undergraduate chemistry courses. Although the enormous interest in catalytic asymmetric CC bond formationr'. 21 has provided a number of practical solutions in other areas, highly enantioselective, catalytic reactions of organolithium reagents generally remain elusive. The complex solution equilibria,['] so characteristic of lithioanions, continually frustrate attempts to discover viable catalytic processes. Two recent pieces of work [4, have made valuable advances towards this goal. Koga et al. have discovered [41 a remarkable catalytic process for the asymmetric benzylation of lithium enolates derived from silyl enol ethers 1 and 3 (Scheme 1). Previously, stereocontrolled