Laboratory animal models for brucellosis research.
Laboratory animal models for brucellosis research.
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DOI：
10.1155/2011/518323
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发表时间：
2011
影响因子：
--
通讯作者：
Santos RL
中科院分区：
文献类型：
--
作者：
Silva TM;Costa EA;Paixão TA;Tsolis RM;Santos RL
布鲁氏菌病是由布鲁氏菌属引起的一种慢性传染病，一种革兰氏阴性兼性胞内病原体，影响人类和动物，对公共卫生和畜牧业产生重大影响。人类布鲁氏菌病被认为是世界上最流行的细菌性人畜共患病，其特征是发热、体重减轻、抑郁、肝/脾肿大、骨关节和生殖器感染。布鲁氏菌发病机制的相关方面已在培养细胞和动物模型中进行了深入研究。小鼠是更常用于研究布鲁氏菌引起的慢性感染的动物模型。该模型最常用于研究布鲁氏菌属的特异性致病因子，以表征宿主免疫应答，并评估治疗剂和疫苗。其他动物物种已被用作布鲁氏菌病模型，包括大鼠、豚鼠和猴。本文讨论了人类和动物布鲁氏菌病的小鼠和其他实验动物模型。
Brucellosis is a chronic infectious disease caused by Brucella spp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.