Characterization of the normal temporal pattern of plasma corticosteroid levels.
Characterization of the normal temporal pattern of plasma corticosteroid levels.
复制标题
血浆皮质类固醇水平正常时间模式的表征。
DOI：
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发表时间：
1971
影响因子：
5.8
通讯作者：
H. P. Krieger
中科院分区：
文献类型：
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作者：
D. Krieger;W. Allen;F. Rizzo;H. P. Krieger
摘要 本研究有 2 个目标： I. 通过在 24 小时周期中每半小时测量血浆皮质类固醇和 ACTH 水平，更准确地描述正常人和库欣综合征患者肾上腺分泌活动的时间过程。二.描述迄今为止缺乏临床最佳和合适的条件来确定和定义血浆皮质类固醇水平（CPOHCS）的正常昼夜节律模式。 1. I. 对四名具有正常活动睡眠和进餐时间模式的对照受试者进行了研究：其中 3 名在“持续喂养”期间进行了重新研究，1 名在恒定葡萄糖给药期间进行了重新研究，并再次在不同的地塞米松方案下进行了研究。 CPOHCS 由给定受试者的 5-10 个峰值组成。 50% 至 75% 的峰值发生在 9 小时内（午夜至上午 9:00），描述了逐渐上升的过程，最大血浆皮质类固醇水平出现在醒来后 1/2-2 小时。随后出现下降趋势，并在上午 11:30 之间出现其他高峰活动……
ABSTRACT The present studies had 2 objectives: I. To delineate more precisely the time course of adrenal secretory activity in the normal human and patients with Cushing's syndrome, by measurement of plasma corticosteroid and ACTH levels half-hourly throughout the 24 hr cycle. II. To describe hitherto lacking clinically optimal and suitable conditions for determination and definition of the normal circadian pattern of plasma corticosteroid levels (CPOHCS). 1. I. Four control subjects with normal activity sleep and meal time patterns were studied: 3 were restudied during “constant feeding,” 1 was restudied during constant glucose administration and again under different dexamethasone regimens. CPOHCS consisted of 5–10 peaks in a given subject. Fifty to 75% of peaks occurred in a 9 hr period (midnight to 9:00 am) describing a gradual upward course with maximum plasma corticosteroid levels occurring 1/2–2 hr following awakening. A downward trend followed with other peaking activity occurring between 11:30 am...