Tumor twitter: cellular communication in the breast cancer stem cell niche.
Tumor twitter: cellular communication in the breast cancer stem cell niche.
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DOI：
10.1158/2159-8290.cd-15-0327
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发表时间：
2015-05
期刊：
影响因子：
28.2
通讯作者：
Wicha MS
中科院分区：
文献类型：
--
作者：
Brooks MD;Wicha MS
构成肿瘤微环境的各种细胞之间的交流在肿瘤的发展中起着重要作用。通过p53缺失小鼠模型，Zhang和同事描述了一个新的反馈回路，涉及乳腺癌干细胞及其由Wnt2、CXCL12和IL6介导的后代。
Communication between the diverse assortment of cells that constitute the tumor microenvironment plays an important role in tumor development. Using a p53 null mouse model, Zhang and colleagues describe a novel feedback loop involving breast cancer stem cells and their progeny mediated by Wnt2, CXCL12, and IL6.