Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence
Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence
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DOI：
10.1016/j.atherosclerosis.2009.03.041
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发表时间：
2009-11-01
期刊：
影响因子：
5.3
通讯作者：
Toschke, Andre Michael
中科院分区：
文献类型：
--
作者：
Reinehr, Thomas;Kleber, Michaela;Toschke, Andre Michael
背景：减肥是降低肥胖相关健康风险的适当途径。方法：对288例肥胖儿童进行为期1年的门诊生活方式干预，分析干预前后体重、口服葡萄糖耐量试验（oGTT）2 h血糖、空腹血糖、血脂、血压和代谢综合征患病率的变化（45%男性;平均年龄12.5岁，平均SDS-BMI 2.48）。将这些数据与186名年龄、性别和体重状况分布相似的未经干预的肥胖儿童进行比较。结果：生活方式干预导致SDS-BMI显著下降（平均值-0.22; 95%CI-0.18至-0.26），而SDS-BMI在未经干预的儿童中显著增加（平均值+0.15; 95%CI + 0.13至+0.18）。与未进行干预的肥胖儿童相比，生活方式干预的儿童代谢综合征患病率显著降低（从19%降至9%;根据IDF定义），腰围、血压和oGTT中的2 h葡萄糖值有所改善。体重减轻的程度与代谢综合征组分的改善量显著相关。特别是，SDS-BMI降低>0.5的儿童表现出代谢综合征的所有组成部分的改善。结论：生活方式干预导致体重减轻和代谢综合征及其组成部分的改善。体重减轻程度与代谢综合征及其组分患病率的改善相关。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Background: Weight loss is the appropriate approach to reduce the obesity-related health risk. However, the effect of lifestyle interventions on the metabolic syndrome prevalence has been rarely studied in obese children.Methods: We analyzed changes of weight status, 2 h glucose levels from oral glucose tolerance tests (oGTT), fasting glucose, lipids, blood pressure, and the prevalence of metabolic syndrome in relation to a 1-year outpatient lifestyle intervention in 288 obese children (45% male; mean age 12.5 years, mean SDS-BMI 2.48). These data were compared to 186 obese children without intervention with similar distributions of age, gender, and weight status.Results: Lifestyle intervention led to a significant decrease of SDS-BMI (mean-0.22; 95% CI-0.18 to -0.26), while SDS-BMI increased significantly in children without intervention ( mean +0.15; 95% CI + 0.13 to + 0.18). Children with lifestyle intervention had a significant decrease of metabolic syndrome prevalence (from 19% to 9%; definition according to IDF) and an improvement of waist circumference, blood pressure, and 2 h glucose values in the oGTT in contrast to obese children without intervention. The degree of weight loss was significantly associated with the amount of improvement of the components of the metabolic syndrome. Particularly, the children with a SDS-BMI reduction >0.5 showed an improvement of all components of the metabolic syndrome.Conclusions: Lifestyle intervention led to weight loss and an improvement of the metabolic syndrome and its components. Degree of weight loss was associated with the improvement of the prevalence of metabolic syndrome and its components. (C) 2009 Elsevier Ireland Ltd. All rights reserved.