Decreased NDRG1 expression is associated with pregnancy loss in mice and attenuates the in vitro decidualization of endometrial stromal cells
Decreased NDRG1 expression is associated with pregnancy loss in mice and attenuates the in vitro decidualization of endometrial stromal cells
复制标题
NDRG1 表达降低与小鼠妊娠失败相关，并减弱子宫内膜基质细胞的体外蜕膜化
DOI：
10.1002/mrd.23238
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发表时间：
2019-07-24
影响因子：
2.5
通讯作者：
Wang, Jian
中科院分区：
文献类型：
--
作者：
Meng, Nan;Yang, Qian;Wang, Jian
胚胎植入是成功怀孕的重要步骤，这个过程中的任何缺陷都可能导致一系列妊娠病理。本研究旨在探讨N-myc下调基因1（NDRG 1）在胚胎着床过程中的作用。结果发现，子宫NDRG 1的表达有一个动态的模式，在发情周期中未怀孕的小鼠和子宫NDRG 1的表达升高，在植入过程中怀孕的小鼠。NDRG 1蛋白信号在妊娠早期着床胚胎附近的初级蜕膜区有明显的积累。此外，小鼠子宫NDRG 1的表达可以通过激活着床或人工蜕膜化来诱导。子宫NDRG 1表达减少与小鼠妊娠丢失相关，与人类复发性流产相关。在体外蜕膜化的小鼠和人子宫内膜基质细胞（ESCs）伴随着增加NDRG 1的表达和下调NDRG 1表达的ESCs有效地抑制蜕膜化。总之，NDRG 1在着床过程中的蜕膜化过程中起重要作用，NDRG 1的异常表达可能与妊娠丢失有关。
Embryo implantation is an essential step for a successful pregnancy, and any defect in this process can lead to a range of pregnancy pathologies. The objective of this study was to explore the role of N-myc downregulated gene 1 (NDRG1) in embryo implantation. It was found that uterine NDRG1 expression has a dynamic pattern during the estrous cycle in nonpregnant mice and that uterine NDRG1 expression was elevated during the implantation process in pregnant mice. The distinct accumulation of NDRG1 protein signals was observed in the primary decidual zone adjacent to the implanting embryo during early pregnancy. Furthermore, uterine NDRG1 expression could be induced by activated implantation or artificial decidualization in mice. Decreased uterine NDRG1 expression was associated with pregnancy loss in mice and was associated with recurrent miscarriages in humans. The in vitro decidualization of both mouse and human endometrial stromal cells (ESCs) was accompanied by increased NDRG1 expression and downregulated NDRG1 expression in ESCs effectively inhibited decidualization. Collectively, these data suggest that NDRG1 plays an important role in decidualization during the implantation process, and the abnormal expression of NDRG1 may be involved in pregnancy loss.