Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index
Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index
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DOI：
10.1148/radiol.14140283
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发表时间：
2015-01-01
期刊：
影响因子：
19.7
通讯作者：
Takahashi, Shoki
中科院分区：
文献类型：
--
作者：
Mori, Naoko;Ota, Hideki;Takahashi, Shoki
目的：为了评估表观扩散系数（ADC）值和Ki-67标记指数管腔型（雌激素受体阳性）乳腺癌的诊断通过biopsiz.Materials和方法：机构审查委员会批准了这项回顾性研究，并要求知情同意书被免除。2009年12月至2012年12月期间，86例腔型浸润性乳腺癌NOS患者的86个病灶接受了磁共振成像，包括动态造影剂增强成像和扩散加权成像，B值为0和1000 sec/mm（2）。常规测量的最小值和平均ADC通过放置感兴趣的区域和直方图分析的像素为基础的ADC数据的整个肿瘤由两个观察者独立进行，并与Ki-67标记指数的手术samples.Results：对于观察者间的可靠性，所有参数的类间相关系数的最小ADC的例外超过0.8，几乎完美的协议。最小ADC值、平均ADC值和第25、50、75位直方图与Ki-67标记指数呈负相关（r分别为-0.49、-0.55、-0.54、-0.53、-0.48）。应用受试者工作特征曲线分析鉴别诊断高增殖（Ki 67.十四个;低增殖（Ki-67，14; n = 42）组显示平均ADC值的最有效阈值低于1097 x 10（-6）mm（2）/sec，敏感性和特异性分别为82%和71%。平均ADC的受试者工作特征曲线下面积（AUC）为0.81。有没有显着差异的AUC之间的参数。结论：考虑到方便的常规做法，作者认为，平均ADC的常规方法将是实用的用于估计Ki-67标记指数。
Purpose: To evaluate the correlation between apparent diffusion coefficient (ADC) values and the Ki-67 labeling index for luminal- type (estrogen receptor-positive) breast cancer not otherwise specified (NOS) diagnosed by means of biopsy.Materials and Methods: The institutional review board approved this retrospective study, and the requirement for informed consent was waived. Between December 2009 and December 2012, 86 patients with 86 lesions with luminal-type invasive breast cancer NOS underwent magnetic resonance imaging, including dynamic contrast material-enhanced imaging and diffusion-weighted imaging with b values of 0 and 1000 sec/mm(2). Conventional measurement of the minimum and mean ADCs by placing regions of interest and histogram analysis of pixel-based ADC data of the entire tumor were performed by two observers independently and correlated with the Ki-67 labeling index of surgical specimens.Results: For the interobserver reliability, interclass correlation coefficients for all parameters with the exception of the minimum ADC exceeded 0.8, indicating almost perfect agreement. The minimum ADC and mean ADC and the 25th, 50th, and 75th percentiles of the histograms showed negative correlations with the Ki-67 labeling index (r = -0.49, -0.55, -0.54, -0.53, and -0.48, respectively). Receiver operating characteristic curve analysis for the differential diagnosis between the high-proliferation (Ki67. 14; n = 44) and low-proliferation (Ki-67, 14; n = 42) groups revealed that the most effective threshold for the mean ADC was lower than 1097 x 10(-6) mm(2)/sec, with sensitivity and specificity of 82% and 71%, respectively. The area under the receiver operating characteristic curve (AUC) was 0.81 for the mean ADC. There were no significant differences in the AUC among the parameters.Conclusion: Considering convenience for routine practice, the authors suggest that the mean ADC of the conventional method would be practical to use for estimating the Ki-67 labeling index.