Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.
Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.
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DOI：
10.1016/j.jacl.2015.12.027
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发表时间：
2016-09
影响因子：
4.4
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Zaid, Maryam;Miura, Katsuyuki;Fujiyoshi, Akira;Abbott, Robert D.;Hisamatsu, Takashi;Kadota, Aya;Arima, Hisatomi;Kadowaki, Sayaka;Torii, Sayuki;Miyagawa, Naoko;Suzuki, Sentaro;Takashima, Naoyuki;Ohkubo, Takayoshi;Sekikawa, Akira;Maegawa, Hiroshi;Horie, Minoru;Nakamura, Yasuyuki;Okamura, Tomonori;Ueshima, Hirotsugu
关键词：
最近发现低密度脂蛋白颗粒（LDL-P）是比LDL胆固醇（LDL-C）更强的心血管疾病（CVD）预测因子。LDL-P是否与亚临床动脉粥样硬化相关，独立于LDL-C，以及其他血脂指标尚未得到充分研究。我们的目的是分析LDL-P与亚临床动脉粥样硬化指标的相关性。我们研究了2006-2008年从日本滋贺草津市随机选择的870名日本男性，年龄40-79岁，无临床CVD，未使用降脂药物。对血脂指标与颈动脉内膜中层厚度（cIMT）和冠状动脉钙化（CAC）[>0 Agatston评分]的横断面相关性进行了研究。LDL-P与cIMT显著正相关，并在调整LDL-C和其他血脂指标后保持这种相关性。虽然这些血脂指标与cIMT呈正相关，但LDL-P的模型校正排除了任何显著关系。较高的LDL-P与显著较高的CAC比值比相关，进一步调整LDL-C并不影响这种关系。与此相反，LDL-P校正后，LDL-C与CAC的相关性不再显著。其他血脂指标减弱了LDL-P与CAC的相关性。同样，当对LDL-P进行模型校正时，这些指标与CAC的相关性减弱。在一个以社区为基础的日本男性样本中，无临床CVD，LDL-P是亚临床动脉粥样硬化的一个可靠标志物，前者独立于LDL-C和其他血脂指标。LDL-C和其他血脂指标与cIMT或CAC的相关性通常不独立于LDL-P。
Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL cholesterol (LDL-C). Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis. We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40–79 years from 2006–2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC) [>0 Agatston score] were examined. LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. While these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made. In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, with the former being independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P.
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影响因子：
24
作者：
Libby, P
通讯作者：
Libby, P
影响因子：
4.4
作者：
Prado, Kimberly Buff;Shugg, Suzanne;Backstrand, Jeffrey R.
通讯作者：
Backstrand, Jeffrey R.
影响因子：
2.8
作者：
Rosenson, RS;Otvos, JD;Freedman, DS
通讯作者：
Freedman, DS
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
5
作者：
Sekikawa, Akira;Ueshima, Hirotsugu;Kuller, Lewis H.
通讯作者：
Kuller, Lewis H.