Biodegradable electrospun PLLA fibers containing the mosquito-repellent DEET
Biodegradable electrospun PLLA fibers containing the mosquito-repellent DEET
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DOI：
10.1016/j.eurpolymj.2019.02.001
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发表时间：
2019-04-01
影响因子：
6
通讯作者：
Di Lorenzo, Maria Laura
中科院分区：
文献类型：
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作者：
Bonadies, Irene;Longo, Alessandra;Di Lorenzo, Maria Laura
该手稿详细介绍了含有驱蚊剂N，N-二乙基-3-甲基苯甲酰胺（DEET）的聚（L-乳酸）（PLLA）纤维的第一个文献实例。该纤维通过静电纺丝制备，无缺陷并且具有1 μ m数量级的均匀直径。热重分析和红外光谱表明，有可能掺入超过50重量%的避蚊胺，然后缓慢释放到环境中。因此，纤维可以用作药物递送装置。进一步的结构分析揭示了含DEET纤维中的PLLA是半结晶的，并且含有在静电纺丝过程中形成的α-晶体。热，形态和结构表征表明，PLLA/DEET电纺纤维具有作为控制释放DEET的新型材料的潜力，再加上这里详细描述的易于制造，可以提供对抗蚊子引起的疾病的创新工具。
The manuscript details the first literature example of fibers of poly(L-lactic acid) (PLLA) containing a mosquito repellent agent, N,N-diethyl-3-methylbenzamide (DEET). The fibers were prepared by electrospinning, are defect-free and have uniform diameter of the order of magnitude of 1 mu m. Thennogravimetry and infrared spectroscopy showed that it is possible to incorporate more than 50 wt% of DEET, which is then slowly released to the environment. As such, the fibers can function as a drug delivery device. Further structural analyses disclosed that PLLA in DEET-containing fibers is semicrystalline, and contains alpha-crystals formed during electrospinning. Thermal, morphological and structural characterization revealed that the PLLA/DEET electrospun fibers have potential as novel material for controlled release of DEET, which, coupled with the ease of fabrication, detailed here, can provide innovative tools for fighting mosquito-caused diseases.