Belonging to a network-microRNAs, extracellular vesicles, and the glioblastoma microenvironment
Belonging to a network-microRNAs, extracellular vesicles, and the glioblastoma microenvironment
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DOI：
10.1093/neuonc/nou292
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发表时间：
2015-05-01
期刊：
影响因子：
15.9
通讯作者：
Bronisz, Agnieszka
中科院分区：
文献类型：
--
作者：
Godlewski, Jakub;Krichevsky, Anna M.;Bronisz, Agnieszka
多形性胶质母细胞瘤（GBM）的复杂性及其独特的病理生理学属于独特的脑微环境及其细胞相互作用。尽管有大量证据表明microRNA在GBM细胞中的作用，但对微环境的不同细胞区室之间可能有助于肿瘤表型的microRNA依赖性通信知之甚少。虽然大多数microRNA存在于细胞内，但在细胞外观察到大量microRNA，通常封装在分泌的细胞外囊泡（EV）中。这些循环/分泌的microRNA的功能尚未在脑肿瘤微环境的背景下探索。确定microRNA如何参与肿瘤细胞和间质之间致癌信号网络的调节，可能会为肿瘤网络增加额外的复杂性，包括细胞间通讯。更重要的是，microRNA/EV信号可能为这种致命疾病提供额外的治疗靶点。
The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tumor cells and stroma is likely to add a needed additional layer of complexity to the tumor network, consisting of intercellular communication. More importantly, microRNA/EV signaling may provide an additional therapeutic target for this deadly disease.