Chiral N,N '-ioxide-Sc(NTf2)(3) complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide source
Chiral N,N '-ioxide-Sc(NTf2)(3) complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide source
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DOI：
10.1039/c7cc00470b
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发表时间：
2017
影响因子：
4.9
通讯作者：
Feng Xiaoming
中科院分区：
文献类型：
--
作者：
Wang Zhengmeng;Lin Lili;Zhou Pengfei;Liu Xiaohua;Feng Xiaoming
以N，N ' - 2 - sc (NTf2)3手性配合物为催化剂，以N-溴代琥珀酰亚胺为溴源和酰胺源，实现了查尔酮的不对称溴胺化反应。在温和的反应条件下，得到了相应的手性溴胺化产物，产率高，dr值高，ee值好（产率高达92%，dr值为93.7，ee值为97%）。
The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by using a chiral N,N′-dioxide-Sc(NTf2)3 complex as an efficient catalyst. The corresponding chiral bromoamination products were obtained in high yields with high dr and good ee values (up to 92% yield, 93 : 7 dr and 97% ee) under mild reaction conditions.