The roles of stress and social support in prostate cancer mortality
The roles of stress and social support in prostate cancer mortality
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DOI：
10.3109/21681805.2015.1079796
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发表时间：
2016-01-02
影响因子：
1.5
通讯作者：
Balter, Katarina
中科院分区：
文献类型：
--
作者：
Jan, Michael;Bonn, Stephanie E.;Balter, Katarina
目的：本研究旨在评估全国前列腺癌男性队列中感知压力、社会支持、疾病进展和死亡率之间的关联。材料和方法：该研究调查了 4105 名接受临床局限性前列腺癌治疗的瑞典男性的压力、悲伤、睡眠习惯和社会支持方面的情况。使用多变量 Cox 回归分析评估这些因素与死亡率之间的关联。结果：与压力水平较低的男性相比，感知压力水平最高的男性前列腺癌特异性死亡率在统计上显着增加（风险比 1.66，95% 置信区间 1.05-2.63）。压力水平高的男性也更容易感到悲伤和睡眠不足。他们能够分享情感问题的人也越来越少，并且无法与伴侣、朋友和家人分享大部分问题。结论：这项研究有助于前列腺癌男性社会心理生活质量研究领域的不断发展。研究结果表明，最初诊断为局部非转移性前列腺癌的患者的前列腺癌特异性死亡率与感知压力之间存在显着相关性。感知压力与各种社会心理因素之间也存在显着关联。这项研究的结果可能有助于采取针对性干预措施，以改善前列腺癌男性的生活质量。
Objective: This study aimed to evaluate the association between perceived stress, social support, disease progression and mortality in a nationwide population-based cohort of men with prostate cancer. Materials and methods: The study surveyed 4105 Swedish men treated for clinically localized prostate cancer regarding stress, grief, sleep habits and social support. Associations between these factors and mortality were assessed using multivariate Cox regression analysis. Results: Men with the highest levels of perceived stress had a statistically significantly increased rate of prostate cancer-specific mortality compared with men with low stress levels (hazard ratio 1.66, 95% confidence interval 1.05-2.63). Men with high stress levels also had a high frequency of grieving and sleep loss. They also had fewer people with whom to share their emotional problems and felt an inability to share most of their problems with partners, friends and family. Conclusions: This study contributes to the growing field of psychosocial quality of life research in men with prostate cancer. The findings show a significant association between prostate cancer-specific mortality and perceived stress in patients initially diagnosed with localized, non-metastatic prostate cancer. Significant associations between perceived stress and various psychosocial factors were also seen. The findings of this study could prove useful to target interventions to improve quality of life in men with prostate cancer.