Small RNAs Worm Up Transgenerational Epigenetics Research.
Small RNAs Worm Up Transgenerational Epigenetics Research.
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DOI：
10.3390/dna1020005
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发表时间：
2021-12
期刊：
影响因子：
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通讯作者：
Grishok A
中科院分区：
文献类型：
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作者：
Grishok A
DNA是大多数生物体繁殖和进化的核心，因为它具有自我复制的基本过程。然而，它也编码了一些因素，这些因素允许表观遗传（不包括在DNA序列中）信息从父母传递给他们的后代以及更远的后代。已知的表观遗传机制包括DNA和染色质的化学修饰，以及调控rna。所有这些因素都可以调节后代的基因表达程序。秀丽隐杆线虫是公认的跨代表观遗传研究的先驱生物。秀丽隐杆线虫表观遗传学的最新进展包括限制rna表观遗传持续时间的控制机制的发现，抵消表观遗传沉默建立的周期性DNA基序，对精子携带的表观遗传的新的机制见解，以及感官经验遗传的诱人例子。本文综述了秀丽隐杆线虫表观遗传学研究的新发现，重点介绍了依赖小rna的跨代表观遗传现象。
DNA is central to the propagation and evolution of most living organisms due to the essential process of its self-replication. Yet it also encodes factors that permit epigenetic (not included in DNA sequence) flow of information from parents to their offspring and beyond. The known mechanisms of epigenetic inheritance include chemical modifications of DNA and chromatin, as well as regulatory RNAs. All these factors can modulate gene expression programs in the ensuing generations. The nematode Caenorhabditis elegans is recognized as a pioneer organism in transgenerational epigenetic inheritance research. Recent advances in C. elegans epigenetics include the discoveries of control mechanisms that limit the duration of RNA-based epigenetic inheritance, periodic DNA motifs that counteract epigenetic silencing establishment, new mechanistic insights into epigenetic inheritance carried by sperm, and the tantalizing examples of inheritance of sensory experiences. This review aims to highlight new findings in epigenetics research in C. elegans with the main focus on transgenerational epigenetic phenomena dependent on small RNAs.