Serum estradiol and risk of stroke in elderly men
Serum estradiol and risk of stroke in elderly men
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DOI：
10.1212/01.wnl.0000254473.88647.ca
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发表时间：
2007-02-20
期刊：
影响因子：
9.9
通讯作者：
Petrovitch, H.
中科院分区：
文献类型：
--
作者：
Abbott, R. D.;Launer, L. J.;Petrovitch, H.
目的：确定血清雌二醇和睾酮水平是否可以预测老年男性人群样本中的中风。方法：对 1991 年至 1993 年参加檀香山亚洲老龄化研究的 2,197 名 71 至 93 岁男性的血清 17 β 雌二醇和睾酮进行了测量。所有这些人都没有流行的中风、冠心病和癌症。参与者的血栓栓塞和出血事件被跟踪至 1998 年底。结果：在随访过程中，124 名男性患中风（9.1/1,000 人年）。年龄调整后，血清雌二醇水平最高五分之一的男性（>= 125 μmol/L [34.1 pg/mL]）的中风风险比雌二醇水平较低的男性高出两倍（14.8 vs 7.3/1,000 人年，p < 0.001）。在较低的五分位数中，中风风险几乎没有差异。对于生物可利用雌二醇以及血栓栓塞和出血事件，研究结果也具有显着性和可比性。对高血压、糖尿病、肥胖、胆固醇浓度、心房颤动和其他特征进行额外调整后，血清雌二醇水平最高五分位的男性与雌二醇水平较低的男性相比，中风的风险仍然较高（相对风险 = 2.2；95% CI = 1.5 至 3.4，p < 0.001）。睾酮与中风风险无关。结论：高水平的血清雌二醇可能与老年男性中风风险升高相关。
Objective: To determine if levels of serum estradiol and testosterone can predict stroke in a population-based sample of elderly men. Methods: Serum 17 beta estradiol and testosterone were measured in 2,197 men aged 71 to 93 years who participated in the Honolulu-Asia Aging Study from 1991 to 1993. All were free of prevalent stroke, coronary heart disease, and cancer. Participants were followed to the end of 1998 for thromboembolic and hemorrhagic events. Results: During the course of follow-up, 124 men developed a stroke (9.1/1,000 person-years). After age adjustment, men in the top quintile of serum estradiol (>= 125 mu mol/L [34.1 pg/mL]) experienced a twofold excess risk of stroke vs men whose estradiol levels were lower (14.8 vs 7.3/1,000 person-years, p < 0.001). Among the lower quintiles, there were little differences in the risk of stroke. Findings were also significant and comparable for bioavailable estradiol and for thromboembolic and hemorrhagic events. After additional adjustment for hypertension, diabetes, adiposity, cholesterol concentrations, atrial fibrillation, and other characteristics, men in the top quintile of serum estradiol continued to have a higher risk of stroke vs those whose estradiol levels were lower (relative hazards = 2.2; 95% CI = 1.5 to 3.4, p < 0.001). Testosterone was not related to the risk of stroke. Conclusions: High levels of serum estradiol may be associated with an elevated risk of stroke in elderly men.