The early bactericidal activity of drugs in patients with pulmonary tuberculosis.
The early bactericidal activity of drugs in patients with pulmonary tuberculosis.
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DOI：
10.1164/arrd.1980.121.6.939
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
A. Jindani;V. Aber;E. Edwards;D. Mitchison
中科院分区：
文献类型：
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作者：
A. Jindani;V. Aber;E. Edwards;D. Mitchison
本文对124例肺结核患者治疗前2周痰结核菌菌落数进行了测定。研究的27种化疗方案包括每日单独使用噻乙松、对氨基水杨酸、吡嗪酰胺、利福平、链霉素、乙胺丁醇和异烟肼以及某些2种药物、3种药物和4种药物的联合给药。硫醋腙和对氨基水杨酸似乎仅具有抑菌作用。在治疗的前2天，计数的平均下降和含有剩余杀菌药物的方案之间的差异大于剩余12天。异烟肼组的早期（0-2天）福尔斯下降幅度比其他药物大得多。利福平的杀菌作用较弱，可能降低了3种药物和4种药物（包括异烟肼）联合用药的杀菌活性。链霉素和吡嗪酰胺单用或2药联用虽仅有轻微杀菌作用，但3药联用方案仍有较好的杀菌效果。
Counts of colony-forming units of Mycobacterium tuberculosis in sputum were done on selective medium during the first 2 wk of treatment of 124 patients with pulmonary tuberculosis. The 27 chemotherapy regimens studied included daily administration of thiacetazone, p-aminosalicylic acid, pyrazinamide, rifampin, streptomycin, ethambutol, and isoniazid alone and certain 2-drug, 3-drug, and 4-drug combinations. Thiacetazone and p-aminosalicylic acid appeared to be only bacteriostatic. The mean fall in counts and the differences between regimens containing the remaining bactericidal drugs were greater during the first 2 days of treatment than during the remaining 12 days. The early (0-to-2-day) falls were much larger with isoniazid than with other drugs. Rifampin was less bactericidal, and may have reduced the bactericidal activity of the 3-drug and 4-drug combinations, including isoniazid. Although streptomycin and pyrazinamide were only slightly bactericidal alone or in a 2-drug combination, the 3-drug regim...