T cell growth factor abrogates concanavalin A-induced suppressor cell function
T cell growth factor abrogates concanavalin A-induced suppressor cell function
复制标题
T 细胞生长因子消除刀豆球蛋白 A 诱导的抑制细胞功能
DOI：
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发表时间：
1981
影响因子：
15.3
通讯作者：
G. Moller
中科院分区：
文献类型：
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作者：
R. Palacios;G. Moller
刀豆蛋白A （Con-A）诱导的抑制性T细胞对T细胞生长因子（TCGF）有增殖反应。TCGF消除了这些细胞对植物血凝素（PHA）和同种异体抗原诱导的淋巴细胞增殖和商陆有丝分裂原（PWM）驱动的免疫球蛋白分泌的抑制活性。con -a激活的抑制T细胞吸收了TCGF的活性，这些活性抑制细胞与TCGF一起预孵育可消除其抑制活性，增加con -a激活的T细胞数量可恢复TCGF的抑制作用。总之，这些发现表明con - a诱导的抑制性T细胞通过降低TCGF的可用水平来发挥其功能。已知环孢素- a （CYA）可以抑制T细胞上TCGF受体的表达，也可以抑制两种指标系统的抑制活性，即PHA或同种异体抗原诱导的DNA合成和pwm诱导的免疫球蛋白合成。CYA使con - a处理的T细胞对TCGF无反应，不能吸收生长因子，支持CYA抑制TCGF受体在T细胞上表达的观点，该药物似乎通过该机制取消con - a诱导的抑制性T细胞功能。
Concanavalin A (Con-A)-induced suppressor T cells were found to respond to T cell growth factor (TCGF) by proliferation. TCGF abrogated the suppressor activity exerted by these cells on phytohemagglutinin (PHA)- and alloantigen- induced lymphocyte proliferation and on pokeweed mitogen (PWM)-driven immunoglobulin secretion. The Con-A-activated suppressor T cells absorbed the TCGF activity, preincubation of these active suppressor cells with TCGF abolished their suppressor activity and addition of increasing numbers of Con-A-activated T cells reverted the abrogator,/ effect of TCGF. Altogether, these findings suggest that Con-A-induced suppressor T cells exert their function by decreasing the available levels of TCGF. Cyclosporin-A (CYA), which is known to inhibit the expression of receptors for TCGF on T cells, also inhibited the suppressor activity as determined in both indicator systems, namely PHA- or alloantigen-induced DNA synthesis and PWM-induced immunoglobulin synthesis. CYA made Con-A-treated T cells unresponsive to TCGF and unable to absorb the growth factor, supporting the notion that CYA inhibits the expression of TCGF receptors on T cells, a mechanism by which this drug seems to abrogate Con-A-induced suppressor T cell function.