Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
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DOI：
10.1097/00001756-200001170-00039
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发表时间：
2000-01-17
期刊：
影响因子：
1.7
通讯作者：
Black, JA
中科院分区：
文献类型：
--
作者：
Fjell, J;Hjelmström, P;Black, JA
terrodotoxin抗性钠电流有助于小直径初级感觉神经元的体细胞和轴突钠电流，其中许多是伤害性的。NaN是最近发现的一种河豚毒素抗性钠通道，优先表达于IB 4标记的背根神经节（DRG）神经元。我们使用了针对NaN特异性肽的抗体，以显示NaN优先定位于坐骨神经中的IB 4阳性无髓纤维的轴突和角膜中的轴突末梢中的沿着。NaN免疫反应也被发现在一些节点的Ranvier的薄髓鞘轴突的坐骨神经，在那里它是并列Kv1.2钾通道免疫反应。NaN的这种分布与NaN钠通道在伤害性传递中的作用一致。NeuroReport 11：199-202（C）2000 Lippincott威廉姆斯和威尔金斯。
Terrodotoxin-resistant sodium currents contribute to the somal and axonal sodium currents of small diameter primary sensory neurons, many of which are nociceptive. NaN is a recently described tetrodotoxin-resistant sodium channel expressed preferentially in IB4-labeled dorsal root ganglion (DRG) neurons. We employed an antibody raised to a NaN specific peptide to show that NaN is preferentially localized along axons of IB4-positive unmyelinated fibers in the sciatic nerve and in axon terminals in the cornea. NaN immunoreactivity was also found at some nodes of Ranvier of thinly myelinated axons of the sciatic nerve, where it was juxtaposed to Kv1.2 potassium channel immunoreactivity. This distribution of NaN is consistent with a role for NaN sodium channels in nociceptive transmission. NeuroReport 11:199-202 (C) 2000 Lippincott Williams & Wilkins.