Browning of adipose tissue and increased thermogenesis induced by Methotrexate.
Browning of adipose tissue and increased thermogenesis induced by Methotrexate.
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DOI：
10.1096/fba.2021-00058
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
Mueller E
中科院分区：
文献类型：
--
作者：
Verma N;Perie L;Corciulo C;Leucht P;Ramkhelawon B;Cronstein BN;Mueller E
甲氨蝶呤（MTX）由于其在免疫细胞中的众所周知的抗炎作用而广泛用于治疗类风湿性关节炎，但其对棕色和米色脂肪组织生物学的影响尚未研究。在这里，我们提出了新的证据，MTX治疗增加了产热基因的基因表达在棕色和米色脂肪组织中的脂肪细胞自主的方式。此外，我们表明用MTX治疗小鼠与抗寒性、改善葡萄糖稳态、减少炎症和减少高脂饮食状态下的脂肪肝有关。总的来说，我们的数据提供了新的证据，MTX对产热组织的作用，以前没有认识到。
Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis due to its well‐known anti‐inflammatory role in immune cells but its impact on brown and beige adipose tissue biology has not yet been investigated. Here, we present the novel evidence that MTX treatment increases the gene expression of thermogenic genes in brown and beige adipose tissues in a fat cell autonomous manner. Furthermore, we show that treatment of mice with MTX is associated with cold resistance, improved glucose homeostasis, decreased inflammation, and reduced hepatosteatosis in high‐fat diet states. Overall, our data provide novel evidence of a role of MTX on thermogenic tissues not previously appreciated.