ACTINOPLANONE-C, ACTINOPLANONE-D, ACTINOPLANONE-E, ACTINOPLANONE-F AND ACTINOPLANONE-G, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
ACTINOPLANONE-C, ACTINOPLANONE-D, ACTINOPLANONE-E, ACTINOPLANONE-F AND ACTINOPLANONE-G, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
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DOI：
10.7164/antibiotics.41.741
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发表时间：
1988-06-01
影响因子：
3.3
通讯作者：
KODAMA, M
中科院分区：
文献类型：
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作者：
KOBAYASHI, K;NISHINO, C;KODAMA, M
我们以前在游动放线菌R-304的培养液中发现了强细胞毒性的游动放线菌酮A（1）和B（2），这促使我们从培养液中进一步分离了五种新的细胞毒性的游动放线菌酮C（3），D（4），E（5），F（6）和G（7）。放线菌酮C（3）和G（7）在小于0.00004 μ g/ml的剂量（IC 50）下显示出非常强的抗HeLa细胞的细胞毒性。3. apprx. 7个是1的N-2和C-4取代基的变体。所有或几个放线菌酮对细菌和稻瘟病菌表现出较强的抗菌活性。测定了放线菌酮A（1）对多种肿瘤细胞的细胞毒作用和对HeLa细胞大分子合成的抑制作用，结果显示1对细胞有较强的细胞毒作用，并对DNA合成有抑制作用。
Our previous finding of strong cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2), in the culture broth of Actinoplanes sp. R-304 stimulated us to isolate further five new cytotoxic polycyclic xanthones which were named actinoplanones C (3), D (4), E (5), F (6) and G (7) from the broth. Actinoplanones C (3) and G (7) showed very strong cytotoxicity against HeLa cells at less than 0.00004 .mu.g/ml dosage (IC50). The structures of 3 .apprx. 7 were varieties of 1 for the N-2 and C-4 substituents. All or several actinoplanones showed strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A (1) was tested for cytotoxicity against various tumor cells and for inhibitory effect on HeLa cell macromolecular synthesis, and 1 exhibited strong cytotoxicity against the cells and inhibitory action on DNA synthesis.