Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function
Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function
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DOI：
10.1016/j.ijcard.2012.03.147
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发表时间：
2013-08-20
影响因子：
3.5
通讯作者：
Williams, Michael J. A.
中科院分区：
文献类型：
--
作者：
Chu, John W.;Jones, Gregory T.;Williams, Michael J. A.
背景：本研究旨在探讨在当代冠状动脉疾病（CAD）治疗背景下，MMP-9或金属蛋白酶组织抑制剂-1（TIMP-1）的内源性活性水平是否与舒张功能障碍（DD）指数相关。方法和结果：我们前瞻性研究了116名患有CAD并保留左心室左心室收缩功能（射血分数> = 45％）的患者。所有患者在招募时均未出现心力衰竭症状，并接受了对罪魁祸首病变的经皮介入治疗（PCI）。收集人口统计学和血管造影特征。使用基于酶联免疫吸附测定的异构体敏感测定法分析血浆样品中 MMP-9 和 TIMP-1 的活性形式。舒张期充盈的常规和组织多普勒超声心动图评估是通过测量舒张期最大早（E）和晚（A）二尖瓣速度、E/A比值、E波减速时间、等容舒张时间、收缩期峰值（S）、舒张期（D）和肺静脉血流的心房反转速度、S/D分数、A与心房持续时间之间的时间差来进行的。反向血流、二尖瓣外侧环舒张早期峰值速度 (E') 和 E/E'。 Active MMP-9 level was higher in patients with more severe phases of DD (normal [n=22]: median 0.57 ng/ml; mild [n=19] 0.83 ng/ml; mild-moderate [n=41] 0.64 ng/ml; moderate or severe [n=34] 1.63 ng/ml; p
Background: This study aimed to investigate whether the endogenous active levels of MMP-9 or tissue inhibitor of metalloproteinases-1 (TIMP-1) were related to indices of diastolic dysfunction (DD) in the setting of contemporary treatment of coronary artery disease (CAD).Methods and results: We prospectively studied 116 patients with CAD and preserved left ventricular LV systolic function (ejection fraction >= 45%). All patients were free of heart failure symptoms at recruitment and underwent percutaneous intervention (PCI) of culprit lesions. Demographic and angiographic characteristics were collected. Plasma samples were analysed for the active form of MMP-9 and TIMP-1 using enzyme-linked immunosorbent assay-based isoform sensitive assays. Conventional and tissue Doppler-echocardiographic assessment of diastolic filling was undertaken with measurements of maximal early (E) and late (A) transmitral velocities in diastole, E/A ratio, E-wave deceleration time, isovolumic relaxation time, peak systolic (S), diastolic (D) and atrial reversal velocities of pulmonary venous flow, S/D fraction, time difference between A and duration of atrial reversal flow, early diastolic peak velocities of the lateral mitral annulus (E') and E/E'. Active MMP-9 level was higher in patients with more severe phases of DD (normal [n=22]: median 0.57 ng/ml; mild [n=19] 0.83 ng/ml; mild-moderate [n=41] 0.64 ng/ml; moderate or severe [n=34] 1.63 ng/ml; p