ELECTROMECHANICAL PROPERTIES OF ARTICULAR-CARTILAGE DURING COMPRESSION AND STRESS RELAXATION
ELECTROMECHANICAL PROPERTIES OF ARTICULAR-CARTILAGE DURING COMPRESSION AND STRESS RELAXATION
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DOI：
10.1038/275448a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
GLIMCHER, MJ
中科院分区：
文献类型：
--
作者：
GRODZINSKY, AJ;LIPSHITZ, H;GLIMCHER, MJ
关节软骨的主要生理功能是作为承重材料。它由胶原蛋白、蛋白聚糖、非胶原蛋白、脂质和细胞组成的有机基质组成，这些基质用水溶胀1，2。它的净固定电荷是负的，与每个深度的己糖胺含量成正比3。当软骨受压时，间质液渗出。这种流体相对于固体基质的流动在控制组织的各种流变特性中起重要作用，例如其在负载下的蠕变变形4 -11。此外，我们已经观察到，当软骨被压缩时，在软骨的表面和最深区域之间诱导可测量的电势差。我们在这里报告我们对这种现象的研究，以定量地将电位的大小、符号和时间依赖性与软骨力学和流体流动的已知特征11，即组织结构、功能和组成联系起来。我们的研究结果表明，电动机制是主要负责的机械到电的转导反应。
THE main physiological function of articular cartilage is to act as a bearing material. It consists of an organic matrix made of collagen, proteoglycans, non-collagenous proteins, lipids and cells that are swollen with water1,2. Its net fixed charge is negative and directly proportional in magnitude to its hexos-amine content at each depth3. When cartilage is compressed, interstitial fluid is exuded. This flow of fluid with respect to the solid matrix plays an important part in controlling various rheological properties of the tissue, such as its creep deformation under load4–11. Also, we have observed that measurable electrical potential differences are induced between the surface and deepest regions of cartilage when it is compressed. We report here our studies of this phenomenon to quantitatively relate the magnitude, sign and time dependence of the electrical potentials to the known features of cartilage mechanics and fluid flow11, that is, in terms of tissue structure, function and composition. Our results suggest that an electrokinetic mechanism is primarily responsible for the mechanical-to-electrical transduction response.