Blood Cadmium and Lead and Chronic Kidney Disease in US Adults: A Joint Analysis
Blood Cadmium and Lead and Chronic Kidney Disease in US Adults: A Joint Analysis
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DOI：
10.1093/aje/kwp248
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发表时间：
2009-11-01
影响因子：
5
通讯作者：
Weaver, Virginia
中科院分区：
文献类型：
--
作者：
Navas-Acien, Ana;Tellez-Plaza, Maria;Weaver, Virginia
环境中的镉和铅暴露很普遍，这两种金属在高暴露水平下都有肾毒性。很少有研究评估低水平镉和临床肾脏结果之间的关联，特别是在联合镉和铅暴露方面。在1999-2006年参加全国健康与营养检查调查的14，778名20岁以上成年人中，血镉和铅的几何平均水平分别为0.41 μ g/L（3.65 nmol/L）和1.58 μ g/dL（0.076 μ mol/L）。调整调查年份、社会人口因素、慢性肾病风险因素和血铅后，白蛋白尿（>= 30 mg/g肌酸酐）、估计肾小球滤过率降低（eGFR）（
Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels. Few studies have evaluated the associations between low-level cadmium and clinical renal outcomes, particularly with respect to joint cadmium and lead exposure. The geometric mean levels of blood cadmium and lead were 0.41 mu g/L (3.65 nmol/L) and 1.58 mu g/dL (0.076 mu mol/L), respectively, in 14,778 adults aged >= 20 years who participated in the National Health and Nutrition Examination Survey (1999-2006). After adjustment for survey year, sociodemographic factors, chronic kidney disease risk factors, and blood lead, the odds ratios for albuminuria (>= 30 mg/g creatinine), reduced estimated glomerular filtration rate (eGFR) (