The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
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DOI：
10.1016/s0014-5793(97)00412-2
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发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Yarden, Y
中科院分区：
文献类型：
--
作者：
Alroy, I;Yarden, Y
配体诱导的受体酪氨酸激酶（RTK）活化导致多种细胞途径的启动，包括增殖、分化和细胞迁移。RTKs的ErbB家族代表了通过形成同源和异源二聚体受体复合物进行信号多样化的模型。每个二聚体受体复合物将通过募集不同组的含有Src同源2-（SH 2-）的效应蛋白来启动不同的信号传导途径。由于存在增强和稳定二聚化但没有配体的致癌受体（ErbB-2）和可以募集新的含SH-2蛋白质但本身缺乏激酶活性的受体（ErbB-3），增加了进一步的复杂性。由此产生的信号网络对胚胎发育和恶性转化具有重要意义。(C)1997年欧洲生物化学学会联合会。
Ligand-induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo- and heterodimeric receptor complexes. Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting a different set of Src homology 2- (SH2-) containing effector proteins. Further complexity is added due to the existence of an oncogenic receptor that enhances and stabilizes dimerization but has no ligand (ErbB-2), and a receptor that can recruit novel SH-2-containing proteins, but is itself devoid of kinase activity (ErbB-3). The resulting signaling network has important implications for embryonic development and malignant transformation. (C) 1997 Federation of European Biochemical Societies.