Neuronal domains in developing neocortex.
Neuronal domains in developing neocortex.
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DOI：
10.1126/science.1496379
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发表时间：
1992-07
期刊：
影响因子：
56.9
通讯作者：
R. Yuste;A. Peinado;L. C. Katz
中科院分区：
文献类型：
--
作者：
R. Yuste;A. Peinado;L. C. Katz
哺乳动物的新皮层由一系列柱状单位组成，其发育过程尚不清楚。荧光钙指示剂Fura-2标记的脑切片的光学记录显示，新生大鼠皮层被划分为不同的领域的自发协同活动的神经元。在切向切片中，这些区域的直径为50至120微米;在冠状切片中，它们跨越几个皮质层，类似于成人皮质中发现的柱状物。在发展中的躯体感觉皮层，域小于，并不同于，桶，这代表从一个单一的触须的感觉输入。每个区域内的神经元通过间隙连接连接。因此，皮层发育过程中的非突触通讯定义了离散的多细胞模式，可以预示成人的功能架构。
The mammalian neocortex consists of a mosaic of columnar units whose development is poorly understood. Optical recordings of brain slices labeled with the fluorescent calcium indicator fura-2 revealed that the neonatal rat cortex was partitioned into distinct domains of spontaneously coactive neurons. In tangential slices, these domains were 50 to 120 micrometers in diameter; in coronal slices they spanned several cortical layers and resembled columns found in the adult cortex. In developing somatosensory cortex, domains were smaller than, and distinct from, the barrels, which represent sensory input from a single vibrissa. The neurons within each domain were coupled by gap junctions. Thus, nonsynaptic communication during cortical development defines discrete multicellular patterns that could presage adult functional architecture.