Effect of Ursodeoxycholic Acid on Liver Function in Children After Successful Surgery for Biliary Atresia
Effect of Ursodeoxycholic Acid on Liver Function in Children After Successful Surgery for Biliary Atresia
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DOI：
10.1542/peds.2008-0986
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发表时间：
2008-12-01
期刊：
影响因子：
8
通讯作者：
Gottrand, Frederic
中科院分区：
文献类型：
--
作者：
Willot, Stephanie;Uhlen, Stephanie;Gottrand, Frederic
目的。尽管熊去氧胆酸已用于治疗儿童的各种胆汁淤积性肝病，但关于其在胆道闭锁中的疗效数据却很少。本研究的目的是评估熊去氧胆酸治疗对胆道闭锁手术成功的儿童肝功能的影响。
患者与方法。我们前瞻性地研究了16例胆道闭锁且肝门肠吻合术成功的儿童（术后结合胆红素浓度：
OBJECTIVES. Although ursodeoxycholic acid has been used to treat various cholestatic liver diseases in children, few data are available about its efficacy in biliary atresia. The aim of this study was to assess the effect of ursodeoxycholic acid treatment on liver function in children who underwent successful surgery for biliary atresia.PATIENTS AND METHODS. We prospectively studied 16 children with biliary atresia who underwent successful portoenterostomies (postoperative conjugated bilirubin concentration: