The effect of change in population size on DNA polymorphism.
The effect of change in population size on DNA polymorphism.
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作者：
F. Tajima
从非平衡种群中随机抽样的DNA序列之间的平均核苷酸差值的期望值和分离位点数的期望值已经被开发出来。结果表明，在种群大小变化较大的情况下，分离位点数受当前种群大小的影响比受核苷酸差异平均数的影响更大，而核苷酸差异平均数受原始种群大小的影响比受分离位点数的影响更大。结果还表明，核苷酸差异的平均数量受群体瓶颈的影响比分离位点的数量更大。
The expected number of segregating sites and the expectation of the average number of nucleotide differences among DNA sequences randomly sampled from a population, which is not in equilibrium, have been developed. The results obtained indicate that, in the case where the population size has changed drastically, the number of segregating sites is influenced by the size of the current population more strongly than is the average number of nucleotide differences, while the average number of nucleotide differences is affected by the size of the original population more severely than is the number of segregating sites. The results also indicate that the average number of nucleotide differences is affected by a population bottleneck more strongly than is the number of segregating sites.