Class I and II human leukocyte antibodies in pediatric haploidentical allograft candidates: prevalence and risk factors
Class I and II human leukocyte antibodies in pediatric haploidentical allograft candidates: prevalence and risk factors
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儿科半相合同种异体移植候选者中的 I 类和 II 类人类白细胞抗体：患病率和危险因素
DOI：
10.1038/s41409-018-0427-7
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发表时间：
2019-01
影响因子：
4.8
通讯作者：
Zhao Xiang Yu
中科院分区：
文献类型：
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作者：
Lv Meng;Zhai Shu Zhen;Wang Yu;Xu Lan Ping;Zhang Xiao Hui;Chen Huan;Chen Yu Hong;Wang Feng Rong;Han Wei;Sun Yu Qian;Cheng Yi Fei;Yan Chen Hua;Mo Xiao Dong;Liu Kai Yan;Chang Ying Jun;Huang Xiao Jun;Zhao Xiang Yu
供者特异性抗人白细胞抗原抗体(DSA)与单倍体相合干细胞移植(Haplo-HSCT)后移植失败(GF)相关。儿科候选人中DSA的患病率和危险因素仍有待确定。在一项前瞻性试验(CHICCTR-OPC-15006672)中，486名血液病儿童被纳入筛查免疫球蛋白G型抗HLAI类和II类抗体的存在。52例(10.7%)患者群反应性抗体(PRA)为I类阳性，24例(4.9%)为II类阳性，13例(2.7%)同时阳性。多因素分析显示，诊断是抗体的独立危险因素，急性淋巴细胞白血病(ALL)患者(HR0.141，95%CI：0.037~0.538，p= 0.004)抗HLAB、DQ和DR的II类PRA和DSA发生率较低，而骨髓增生异常综合征(MDS)患者I、II类PRA(HR4.790，95%CI：1.010~22.716，P= 0.049)和抗HLAA、B、C、DP、DQ的DSA发生率较高。年龄较大(>；12比HLA12)与抗≤-DP的DSA相关(HR0.194，95%CI：0.041-0.918，p= 0.039)。我们的发现为接受半造血干细胞移植的儿科候选人的PRA和DSA的患病率和危险因素提供了新的证据，可能有利于抗HLA抗体的监测和供者的选择。
Donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) were associated with graft failure (GF) following haploidentical stem cell transplantation (Haplo-HSCT). The prevalence and risk factors of DSAs in pediatric candidates remain to be determined. In a prospective trial (ChiCTR-OPC-15006672), 486 children with hematological diseases were enrolled to screen for the presence of anti-HLA class I and II antibodies of immunoglobulin G type. Fifty two patients (10.7%) demonstrated positive panel-reactive antibody (PRA) for class I; 24 (4.9%), for class II; and 13 (2.7%), for both. Multivariate analysis showed diagnosis was the independent risk factor for antibodies, as acute lymphoblastic leukemia (ALL) patients (HR0.141, 95% CI: 0.037–0.538,p= 0.004) had a lower incidence of class II PRAs and DSAs against HLA-B, DQ, and DR, whereas myelodysplastic syndrome (MDS) patients had a higher incidence of PRAs for both class I and class II (HR4.790, 95% CI: 1.010–22.716,p= 0.049), and DSAs against HLA-A, B, C, DP, and DQ. Older age (>12 vs. ≤12) was associated with DSAs against HLA-DP (HR0.194, 95% CI: 0.041–0.918,p= 0.039). Our findings provided novel evidence for prevalence and risk factors for PRAs and DSAs in pediatric candidates receiving haplo-HSCT, possibly benefiting anti-HLA antibody monitoring and donor selection.
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DOI：
10.1016/j.bbmt.2015.05.001
发表时间：
2015-08
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Ciurea SO;Thall PF;Milton DR;Barnes TH;Kongtim P;Carmazzi Y;López AA;Yap DY;Popat U;Rondon G;Lichtiger B;Aung F;Afshar-Kharghan V;Ma Q;Fernández-Viña M;Champlin RE;Cao K
通讯作者：
Cao K
影响因子：
6.2
作者：
Haneda M;Owaki M;Kuzuya T;Iwasaki K;Miwa Y;Kobayashi T
通讯作者：
Kobayashi T
HLA同种免疫与镰状细胞疾病的多重输血患者中的RBC抗体有关。
影响因子：
3.2
作者：
McPherson, Marianne E.;Anderson, Alan R.;Castillejo, Marta-Ines;Hillyer, Christopher D.;Bray, Robert A.;Gebel, Howard M.;Josephson, Cassandra D.
通讯作者：
Josephson, Cassandra D.
影响因子：
20.3
作者：
Spellman, Stephen;Bray, Robert;Anasetti, Claudio
通讯作者：
Anasetti, Claudio
影响因子：
10.5
作者：
J. Burchenal;M. Dowling;Charlotte T. C. Tan
通讯作者：
J. Burchenal;M. Dowling;Charlotte T. C. Tan