Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD).
Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD).
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DOI：
10.3978/j.issn.2078-6891.2015.036
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chen Mingyi
中科院分区：
文献类型：
--
作者：
Matsukuma Karen E;Wei Dongguang;Sun Kai;Ramsamooj Rajendra;Chen Mingyi
Graft versus host disease (GVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) that typically manifests as injury to the skin, gastrointestinal mucosa, and liver. In some cases, hepatic GVHD may be histologically indistinguishable from other disorders such as infection and drug-induced liver injury (DILI). Additionally, clinical signs and symptoms are frequently confounded by the superimposed effects of pretransplant chemoradiotherapy, immunotherapy (IT) (targeted to the underlying malignancy), GVHD prophylaxis, and infection. Thus, careful attention to and correlation with clinical findings, laboratory values, and histologic features is essential for diagnosis. This review, aimed at the practicing pathologist, will discuss current clinical and histologic criteria for GVHD, the approach to diagnosis of hepatic GVHD, and features helpful for distinguishing it from other entities in the differential diagnosis..
