Mast-cell infiltration of airway smooth muscle in asthma
Mast-cell infiltration of airway smooth muscle in asthma
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DOI：
10.1056/nejmoa012705
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发表时间：
2002-05-30
影响因子：
158.5
通讯作者：
Pavord, ID
中科院分区：
文献类型：
--
作者：
Brightling, CE;Bradding, P;Pavord, ID
背景：哮喘和嗜酸性支气管炎的特点是下呼吸道粘膜下层有相似的炎性浸润物。然而，嗜酸性支气管炎与哮喘的不同之处在于，前者没有可变的气流阻塞或气道高反应性。方法：对17例哮喘患者、13例嗜酸性支气管炎患者和11例健康体检者的支气管活检标本进行免疫组织化学分析。结果：两组患者均表现为黏膜下嗜酸性粒细胞增多、基底膜和网状层增厚。相比之下，哮喘患者气道平滑肌束中类胰蛋白酶阳性的肥大细胞数量(中位数5.1个/平方毫米[范围0-33.3])显著高于嗜酸性支气管炎患者(中位数0个/平方毫米；范围0-4.8)和正常对照组(中位数0个/平方毫米[范围0-6.4]；P
Background: Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway hyperresponsiveness in the former condition. We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.Methods: Immunohistochemical analysis of bronchial-biopsy specimens was completed in 17 subjects with asthma, 13 subjects with eosinophilic bronchitis, and 11 normal controls recruited from two centers.Results: Both groups with disease had a similar degree of submucosal eosinophilia and thickening of the basement membrane and lamina reticularis. By contrast, the number of tryptase-positive mast cells in the bundles of airway smooth muscle from subjects with asthma (median, 5.1 mast cells per square millimeter of smooth muscle [range, 0 to 33.3]) was substantially higher than that in subjects with eosinophilic bronchitis (median, 0 mast cells per square millimeter; range, 0 to 4.8) and that in normal controls (median, 0 mast cells per square millimeter [range, 0 to 6.4]; P