Total cerebral blood flow and total brain perfusion in the general population: The Rotterdam Scan Study
Total cerebral blood flow and total brain perfusion in the general population: The Rotterdam Scan Study
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DOI：
10.1038/sj.jcbfm.9600526
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发表时间：
2008-02-01
影响因子：
6.3
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
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作者：
Vernooij, Meike W.;van der Lugt, Aad;Breteler, Monique M. B.
脑灌注减少可能有助于脑血管和神经退行性疾病的发展。对一般人群的脑灌注知之甚少，因为大多数测量技术对于大群健康个体的应用来说都太具侵入性。脑血流量（tCBF）可以通过磁共振成像（MRI）无创测量，但与脑容量高度相关。我们通过将tCBF除以脑体积来计算总脑灌注，并将tCBF与总脑灌注进行比较，研究总脑灌注的决定因素。其次，我们研究了是否具有低tCBF或低总脑灌注的人具有较大体积的白色病变（WML）。本研究基于鹿特丹研究（一项基于人群的队列研究）中的892名60 - 91岁的受试者。我们进行了二维（2D）相位对比MRI测量tCBF。定量评估脑体积和WML体积。通过访谈和体格检查评估心血管决定因素。我们用线性回归模型评估了心血管决定因素和血流测量之间的关系，并对年龄和性别进行了调整。使用一般线性模型评估tCBF或总脑灌注与WML体积之间的关联。我们发现，tCBF和总脑灌注的决定因素有很大不同，因为脑体积对tCBF值的影响很大。与高全脑灌注的人相比，低全脑灌注的人具有显著更大的WML体积。需要进行前瞻性研究，以阐明是否灌注不足有助于WML的形成或组织损伤，表现为WML，导致脑灌注不足。
Reduced cerebral perfusion may contribute to the development of cerebrovascular and neurodegenerative diseases. Little is known on cerebral perfusion in the general population, as most measurement techniques are too invasive for application in large groups of healthy individuals. Total cerebral blood flow (tCBF) can be noninvasively measured by magnetic resonance imaging (MRI) but is highly correlated with brain volume. We calculated total brain perfusion by dividing tCBF by brain volume, and we investigated determinants of total brain perfusion in comparison with tCBF. Secondly, we studied whether persons with a low tCBF or low total brain perfusion have a larger volume of white matter lesions (WML). This study is based on 892 persons aged 60 to 91 years from the Rotterdam Study, a population-based cohort study. We performed two-dimensional (2D) phase-contrast MRI for tCBF measurement. Brain volume and WML volume were quantitatively assessed. Cardiovascular determinants were assessed by interview and physical examination. We assessed associations between cardiovascular determinants and flow measures with linear regression models, adjusted for age and sex. Associations between tCBF or total brain perfusion and WML volume were assessed using general linear models. We found that determinants of tCBF and total brain perfusion differed largely due to the large influence of brain volume on tCBF values. Persons with low total brain perfusion had a significantly larger WML volume compared with those with high total brain perfusion. Prospective studies are required to unravel whether hypoperfusion contributes to WML formation or that tissue damage, manifested by WML, leads to brain hypoperfusion.