Category-specific visual responses of single neurons in the human medial temporal lobe
Category-specific visual responses of single neurons in the human medial temporal lobe
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DOI：
10.1038/78868
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发表时间：
2000-09-01
影响因子：
25
通讯作者：
Fried, I
中科院分区：
文献类型：
--
作者：
Kreiman, G;Koch, C;Fried, I
海马、杏仁核和内嗅皮层接收来自专门处理复杂视觉刺激的颞叶新皮层区域的会聚输入，并且在视觉图像的表征和识别中是重要的。通过对人类海马、内嗅皮层和杏仁核中427个单个神经元的记录，我们发现在一次又一次的试验中，单个神经元的类别特异性放电程度非常高。在记录的神经元中，有14%的神经元选择性地对不同类别的视觉刺激做出反应，包括面孔、自然场景和房屋、名人和动物。基于单个神经元的放电率，可以预测刺激类别，平均误差概率为0.24。在海马体中，对空间布局做出反应的神经元比例大于对其他类别做出反应的神经元比例。我们的数据提供了直接支持的作用，人类内侧颞区在表示不同类别的视觉刺激。
The hippocampus, amygdala and entorhinal cortex receive convergent input from temporal neocortical regions specialized for processing complex visual stimuli and are important in the representation and recognition of visual images. Recording from 427 single neurons in the human hippocampus, entorhinal cortex and amygdala, we found a remarkable degree of category-specific firing of individual neurons on a trial-by-trial basis. Of the recorded neurons, 14% responded selectively to visual stimuli from different categories, including faces, natural scenes and houses, famous people and animals. Based on the firing rate of individual neurons, stimulus category could be predicted with a mean probability of error of 0.24. In the hippocampus, the proportion of neurons responding to spatial layouts was greater than to other categories. Our data provide direct support for the role of human medial temporal regions in the representation of different categories of visual stimuli.