Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster
Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster
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DOI：
10.1002/cne.21146
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发表时间：
2007-01-01
影响因子：
2.5
通讯作者：
Taghert, Paul
中科院分区：
文献类型：
--
作者：
Helfrich-Foerster, Charlotte;Shafer, Orte T.;Taghert, Paul
表达时钟基因的外侧神经元对于果蝇的运动活动节律至关重要。传统上，这些神经元分为三组：背侧神经元（LNd）、大腹侧神经元（1-LNv）和小腹侧神经元（s-LNv），其中后一组由表达神经肽色素分散因子（PDF）的四个神经元和第五个 PDF 阴性神经元组成。到目前为止，只有 1-LNv 和 PDF 阳性 s-LNv 被证明可以投射到附属髓质中，附属髓质是一种小神经网，包含几种昆虫的昼夜节律起搏器中心。我们在这里表明，其他外侧神经元也在附属髓质中形成树状，主要形成突触后位点。 1-LNv 和 LNd 在解剖学上都非常适合连接附属髓质。 1-LNv 可以接收来自 Hofbauer-Buchner 孔眼的同侧光输入，而 LNd 主要侵入对侧副髓质，因此可以接收来自对侧的光输入。 LNd 和 1-LNv 在中期变态期间分化。它们彼此非常接近，并且与第五个 PDF 阴性 s-LNv 非常接近，这表明这些细胞群可能源自共同的前体细胞。
The clock-gene-expressing lateral neurons are essential for the locomotor activity rhythm of Drosophila melanogaster. Traditionally, these neurons are divided into three groups: the dorsal lateral neurons (LNd), the large ventral lateral neurons (1-LNv), and the small ventral lateral neurons (s-LNv), whereby the latter group consists of four neurons that express the neuropeptide pigment-dispersing factor (PDF) and a fifth PDF-negative neuron. So far, only the 1-LNv and the PDF-positive s-LNv have been shown to project into the accessory medulla, a small neuropil that contains the circadian pacemaker center in several insects. We show here that the other lateral neurons also arborize in the accessory medulla, predominantly forming postsynaptic sites. Both the 1-LNv and LNd are anatomically well suited to connect the accessory medullae. Whereas the 1-LNv may receive ipsilateral photic input from the Hofbauer-Buchner eyelet, the LNd invade mainly the contralateral accessory medulla and thus may receive photic input from the contralateral side. Both the LNd and the 1-LNv differentiate during midmetamorphosis. They do so in close proximity to one another and the fifth PDF-negative s-LNv, suggesting that these cell groups may derive from common precursors.