Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography
Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography
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DOI：
10.1523/jneurosci.1311-05.2005
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发表时间：
2005-09-28
影响因子：
5.3
通讯作者：
Rushworth, MFS
中科院分区：
文献类型：
--
作者：
Croxson, PL;Johansen-Berg, H;Rushworth, MFS
前额叶皮质（PFC）区域的功能受其解剖连接的限制。关于人类PFC连接的定量信息很少，相反，我们对灵长类动物PFC连接的了解来自于对猕猴的追踪研究。皮层下区域的连接，其中白质穿透和扩散各向异性最大，可以通过扩散加权成像（DWI）束状图研究。因此，我们在4只猕猴和10个人类半球中使用DWI束状图来比较PFC区域与9个皮质下区域的连接，包括几个束状核和几个皮质下核。每个PFC和每个皮质下区域都有不同的连接模式。由于一些神经束包含与后皮层区域的连接，因此也可以推断PFC与后皮层区域的连接模式。值得注意的是，在这两个物种中，有可能识别出以相似的PFC区域为中心的类似回路；在这两个物种中，PFC区域可能与其他大脑区域具有相似的区域特异性功能相互作用模式。在一个传统上属于人类PFC的区域，即脑膜部的情况下，连接的分布与猕猴的PFC区域没有任何联系，相反，与猕猴腹侧运动前区域的模式相似。DWI方法的一些局限性是显而易见的；胼胝体的高扩散各向异性使得相邻扣带区的连接概率值难以比较。
The functions of prefrontal cortex (PFC) areas are constrained by their anatomical connections. There is little quantitative information about human PFC connections, and, instead, our knowledge of primate PFC connections is derived from tracing studies in macaques. The connections of subcortical areas, in which white matter penetration and hence diffusion anisotropy are greatest, can be studied with diffusion-weighted imaging (DWI) tractography. We therefore used DWI tractography in four macaque and 10 human hemispheres to compare the connections of PFC regions with nine subcortical regions, including several fascicles and several subcortical nuclei. A distinct connection pattern was identified for each PFC and each subcortical region. Because some of the fascicles contained connections with posterior cortical areas, it was also possible to draw inferences about PFC connection patterns with posterior cortical areas. Notably, it was possible to identify similar circuits centered on comparable PFC regions in both species; PFC regions probably engage in similar patterns of regionally specific functional interaction with other brain areas in both species. In the case of one area traditionally assigned to the human PFC, the pars opercularis, the distribution of connections was not reminiscent of any macaque PFC region but, instead, resembled the pattern for macaque ventral premotor area. Some limitations to the DWI approach were apparent; the high diffusion anisotropy in the corpus callosum made it difficult to compare connection probability values in the adjacent cingulate region.