Antibodies against hair follicles are associated with alopecia totalis in autoimmune polyendocrine syndrome type I
Antibodies against hair follicles are associated with alopecia totalis in autoimmune polyendocrine syndrome type I
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DOI：
10.1046/j.1523-1747.1999.00778.x
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发表时间：
1999-12-01
影响因子：
6.5
通讯作者：
Kämpe, O
中科院分区：
文献类型：
--
作者：
Hedstrand, H;Perheentupa, J;Kämpe, O
在常染色体隐性遗传性自身免疫性多内分泌综合征I型(APS I)患者中，有针对几个内分泌和非内分泌器官的自身抗体。斑秃出现在约三分之一的患者中，通常以更严重的形式出现，如全面性脱发或全面性脱发。用39例APS I患者血清1：150稀释液对正常人头皮冰冻切片进行间接免疫荧光染色。观察到两种毛囊染色模式。在5例(13%)APS I血清中可见生长期毛囊中分化基质、角质形成细胞和皮质角质形成细胞的细胞质染色。这5例患者均为全脱发，占8例全脱发患者的63%(P
In the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) patients have autoantibodies directed against several endocrine and nonendocrine organs. Alopecia areata is present in about one-third of the patients and usually in the more severe forms, alopecia universalis or totalis. Sera from 39 patients with APS I, diluted 1:150, were used in indirect immunofluorescence staining of cryo-sections from normal human scalp. Two hair follicle staining patterns were observed. A cytoplasmic staining of the differentiating matrix, cuticle, and cortex keratinocytes in the anagen hair follicle was seen in five (13%) APS I sera. All these five patients had alopecia totalis, representing 63% of the eight patients with alopecia totalis (p