Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer
Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer
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DOI：
10.1111/cas.14378
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发表时间：
2020-05-01
期刊：
影响因子：
5.7
通讯作者：
Tahara, Hidetoshi
中科院分区：
文献类型：
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作者：
Koi, Yumiko;Tsutani, Yasuhiro;Tahara, Hidetoshi
端粒G尾（G - tail）在维持染色体稳定性方面起着至关重要的作用。在这项研究中，我们评估了乳腺癌（BC）患者和无癌个体的白细胞G尾长度，并评估了G尾长度与乳腺癌存在之间的关联。与无癌个体相比，在乳腺癌患者中观察到中位G尾长度显著缩短，且在乳腺癌早期阶段就已发现。我们的研究表明，白细胞G尾长度可能是乳腺癌检测的一个潜在生物标志物。
The telomere G-tail (G-tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G-tail length of breast cancer (BC) patients and cancer-free individuals and evaluated the association between the G-tail length and the presence of BC. A significant shortening of the median G-tail length was observed in BC patients compared with cancer-free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G-tail length might be a potential biomarker for BC detection.