A new lead to NLRP3 inhibition.
A new lead to NLRP3 inhibition.
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DOI：
10.1084/jem.20171848
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发表时间：
2017-11-06
期刊：
影响因子：
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通讯作者：
Dixit VM
中科院分区：
文献类型：
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作者：
Lamkanfi M;Dixit VM
靶向炎性小体传感器NLRP3的小分子抑制剂的发现为选择性炎性小体阻滞剂的开发提供了一条新的途径，在广泛的人类疾病中具有潜在的治疗益处（在本期中，见Jiang等人）。一种靶向炎性小体传感器NLRP3的小分子抑制剂的发现，为开发选择性炎性小体阻滞剂提供了一条新途径，在广泛的人类疾病中具有潜在的治疗益处（在本期中，见Jiang等人，https://doi.org/10.1084/jem.20171419）。
The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al.). The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).