Mitochondrial signaling: forwards, backwards, and in between.
Mitochondrial signaling: forwards, backwards, and in between.
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DOI：
10.1155/2013/351613
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发表时间：
2013
影响因子：
--
通讯作者：
Zuckerbraun BS
中科院分区：
文献类型：
--
作者：
Whelan SP;Zuckerbraun BS
线粒体是一种半自主的细胞器，是几乎所有真核细胞的定义特征。它们对能量产生至关重要，但越来越多的证据表明它们在广泛的细胞信号传导和稳态中发挥重要作用。在过去的半个世纪，随着控制线粒体生物发生的多种转录因子和辅因子的发现，我们对线粒体功能的核控制的理解已经扩大。最近，响应于线粒体信息传递的核变化已经导致逆行线粒体信号传导的表征，其中线粒体具有改变核基因表达的能力。线粒体也是应激反应或质量控制的其他组分的组成部分，包括ROS信号传导、未折叠蛋白反应、线粒体自噬和生物发生。这些途径的线粒体信号进行了讨论。
Mitochondria are semiautonomous organelles that are a defining characteristic of almost all eukaryotic cells. They are vital for energy production, but increasing evidence shows that they play important roles in a wide range of cellular signaling and homeostasis. Our understanding of nuclear control of mitochondrial function has expanded over the past half century with the discovery of multiple transcription factors and cofactors governing mitochondrial biogenesis. More recently, nuclear changes in response to mitochondrial messaging have led to characterization of retrograde mitochondrial signaling, in which mitochondria have the ability to alter nuclear gene expression. Mitochondria are also integral to other components of stress response or quality control including ROS signaling, unfolded protein response, mitochondrial autophagy, and biogenesis. These avenues of mitochondrial signaling are discussed in this review.
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影响因子：
11.4
作者：
Biswas, G;Adebanjo, OA;Avadhani, NG
通讯作者：
Avadhani, NG
影响因子：
11.8
作者：
Haynes, Cole M.;Petrova, Kseniya;Ron, David
通讯作者：
Ron, David
DOI：
10.1083/jcb.200211104
发表时间：
2003-05-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Biswas G;Anandatheerthavarada HK;Zaidi M;Avadhani NG
通讯作者：
Avadhani NG
影响因子：
5.6
作者：
Chen SD;Yang DI;Lin TK;Shaw FZ;Liou CW;Chuang YC
通讯作者：
Chuang YC
影响因子：
5.3
作者：
FISHER, RP;CLAYTON, DA
通讯作者：
CLAYTON, DA