Controllable loading and release of nanodrugs in polymeric vesicles
Controllable loading and release of nanodrugs in polymeric vesicles
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DOI：
10.1016/j.giant.2022.100126
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发表时间：
2022-10
期刊：
影响因子：
7
通讯作者：
Junwei Zhou;Yixin Zhang;Rong Wang
中科院分区：
文献类型：
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作者：
Junwei Zhou;Yixin Zhang;Rong Wang
纳米药物主要包括脂质体纳米药物、聚合物纳米药物、蛋白质纳米药物、药物纳米晶体和无机纳米药物，通常表现出比常规小分子药物更高的效率。聚合物囊泡由于具有稳定性好、易于功能化、可规模化生产等优点，在药物载药和释放方面受到广泛关注。亲水腔和疏水囊泡壁可同时包裹亲水性和疏水性药物，有利于发挥药物的协同治疗作用。本文综述了纳米药物在聚合物囊泡中的负载和释放。综述了聚合物囊泡在单药、多药载药以及聚合物与纳米粒的共组装等方面的应用。综述了高分子囊泡在药物靶向转运、药物释放动力学和药物刺激响应性控释等方面的研究进展。
Nanomedicines, mainly consisting of liposome nanodrugs, polymer nanodrugs, protein nanodrugs, drug nanocrystals and inorganic nanodrugs, usually show higher efficiency than conventional small molecular drugs. Polymeric vesicles, owing to the advantages of good stability, easy functionalization, and large-scale production, have received extensive attention in drug loading and release. The hydrophilic cavity and hydrophobic vesicle wall can simultaneously encapsulate hydrophilic and hydrophobic drugs, which was beneficial to exert the synergistic therapeutic effect of drugs. In this review, we focused on the loading and release of nanodrugs in polymeric vesicles. The application of polymeric vesicles for single, multi-drug loading and co-assembly of polymers and nanoparticles were reviewed. The research progress of polymeric vesicles in the fields of targeted transport, drug release kinetics and stimuli-responsive controlled release of drugs was discussed.