Efficient construction of a 3C-xanthone-linked 3C-chromone scaffold by novel double Michael additions and cyclizations.
Efficient construction of a 3C-xanthone-linked 3C-chromone scaffold by novel double Michael additions and cyclizations.
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DOI：
10.1021/ol101100d
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发表时间：
2010-07
期刊：
影响因子：
5.2
通讯作者：
Fuchun Xie;Hong Chen;Youhong Hu
中科院分区：
文献类型：
--
作者：
Fuchun Xie;Hong Chen;Youhong Hu
开发了一种新的碱促进的2-甲基-3-（1-炔基）色酮级联反应，以制备3C-咕吨酮连接的3C-色酮支架。该串联方法涉及多个反应，例如在温和条件下的迈克尔加成/环化，而没有过渡金属催化剂和惰性气氛。
A novel base-promoted cascade reaction of 2-methyl-3-(1-alkynyl)chromones to produce a 3C-xanthone-linked 3C-chromone scaffold has been developed. This tandem process involves multiple reactions such as Michael additions/cyclizations under mild conditions without a transition metal catalyst and inert atmosphere.