Chronic Liver Disease and Mitochondrial Antibodies: A Family Study
Chronic Liver Disease and Mitochondrial Antibodies: A Family Study
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慢性肝病和线粒体抗体：一项家庭研究
DOI：
10.1136/bmj.1.5793.146
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发表时间：
1972
影响因子：
--
通讯作者：
S. Sherlock
中科院分区：
文献类型：
--
作者：
J. G. Walker;D. Bates;D. Doniach;P. Ball;S. Sherlock
两姐妹患有原发性胆道疾病和伴有高滴度线粒体和其他自身抗体的自身免疫性甲状腺炎。他们已故的母亲可能患有类似的疾病。在同一个家庭中，两兄弟有多种自身免疫反应，包括线粒体抗体，但肝功能测试结果正常。另有10名近亲接受了调查。在先证者或她的亲属中没有发现澳大利亚抗原。
Two sisters had primary biliary disease and associated autoimmune thyroiditis with high titres of mitochondrial and other autoantibodies. Their deceased mother possibly suffered from similar disorders. In the same family two brothers had multiple autoimmune reactions, including mitochondrial antibodies, but liver function tests gave normal results. Ten other close relatives were investigated. Australia antigen was not found in the proband or her relatives.