Differential regional gray matter volumes in patients with on-line game addiction and professional gamers.
Differential regional gray matter volumes in patients with on-line game addiction and professional gamers.
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DOI：
10.1016/j.jpsychires.2012.01.004
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发表时间：
2012-04
影响因子：
4.8
通讯作者：
Renshaw PF
中科院分区：
文献类型：
--
作者：
Han DH;Lyoo IK;Renshaw PF
在线游戏成瘾（POGA）患者和专业视频游戏玩家长时间玩视频游戏，但他们的在线游戏体验非常不同的后果。由前扣带回、丘脑和枕颞区组成的大脑区域可能会增加成为职业玩家或POGA的可能性。招募了20名POGA，17名职业玩家和18名健康对照受试者（HC）。所有磁共振成像（MRI）均在1.5 Tesla Espree MRI扫描仪（SIEMENS，埃尔兰根，德国）上进行。使用统计参数映射（SPM 5）的双样本t检验对各组之间的灰质体积进行体素比较。与HC相比，POGA组的冲动性和持续性错误增加，左侧丘脑灰质体积增加，但颞下回、右侧枕中回和左侧枕下回的灰质体积减少。与HC相比，前游戏者左侧扣带回的灰质体积增加，而左侧枕中回和右侧颞下回的灰质体积减少。此外，与POGA组相比，职业玩家组的左侧扣带回灰质体积增加，左侧丘脑灰质体积减少。目前的研究表明，增加灰质体积的左扣带回在职业玩家和POGA的左丘脑可能有助于职业玩家和POGA的不同临床特征。
Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.