Risk factors for major depression during midlife among a community sample of women with and without prior major depression: are they the same or different?
Risk factors for major depression during midlife among a community sample of women with and without prior major depression: are they the same or different?
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DOI：
10.1017/s0033291714002773
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发表时间：
2015-06-01
影响因子：
6.9
通讯作者：
Joffe, H.
中科院分区：
文献类型：
--
作者：
Bromberger, J. T.;Schott, L.;Joffe, H.
背景。女性在中年期间首次罹患重度抑郁症 (MDD) 的可能性非常大。目前尚不清楚终生首次发病和复发性 MDD 的危险因素是否不同。识别这些风险因素可以提供更有针对性的抑郁症筛查和早期干预。本研究旨在评估终生精神和健康史、人格特征、更年期状况以及随时间变化的因素（例如，症状，是 13 次年度随访中首次发作或复发 MDD 的独立危险因素。方法。 443 名年龄在 42 岁至 52 岁之间的女性参加了匹兹堡的全国妇女健康研究，并参加了心理健康研究。精神病学访谈获得了基线时终生精神疾病和每年 MDD 发作的信息。每年收集心理社会和健康相关数据。对基线时有或没有 MDD 病史的女性分别进行 Cox 多变量分析。结果。基线时没有终生 MDD 的女性在中年期间患 MDD 的风险低于有 MDD 病史的女性（28% 对 59%），而且她们的风险状况也不同。基线之前和随访期间的健康状况对功能的感知（ps
Background. Women's vulnerability for a first lifetime-onset of major depressive disorder (MDD) during midlife is substantial. It is unclear whether risk factors differ for first lifetime-onset and recurrent MDD. Identifying these risk factors can provide more focused depression screening and earlier intervention. This study aims to evaluate whether lifetime psychiatric and health histories, personality traits, menopausal status and factors that vary over time, e.g. symptoms, are independent risk factors for first-onset or recurrent MDD across 13 annual follow-ups.Method. Four hundred and forty-three women, aged 42-52 years, enrolled in the Study of Women's Health Across the Nation in Pittsburgh and participated in the Mental Health Study. Psychiatric interviews obtained information on lifetime psychiatric disorders at baseline and on occurrences of MDD episodes annually. Psychosocial and health-related data were collected annually. Cox multivariable analyses were conducted separately for women with and without a MDD history at baseline.Results. Women without lifetime MDD at baseline had a lower risk of developing MDD during midlife than those with a prior MDD history (28% v. 59%) and their risk profiles differed. Health conditions prior to baseline and during follow-ups perception of functioning (ps