Interleukin-17F gene polymorphisms in Korean patients with Behcet's disease
Interleukin-17F gene polymorphisms in Korean patients with Behcet's disease
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DOI：
10.1007/s00296-008-0664-y
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发表时间：
2008-12-01
影响因子：
4
通讯作者：
Kim, Seong-Kyu
中科院分区：
文献类型：
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作者：
Jang, Won-Cheoul;Nam, Yun-Hyoung;Kim, Seong-Kyu
IL-17是一种新的细胞因子，其特点是能够诱导几种类型的细胞分泌促炎细胞因子，用于各种炎症性疾病。本研究分析IL-17F基因多态性对疾病易感性和临床特征的影响。采用自动测序技术对99例白塞病（BD）患者和114例对照进行基因分型，分析IL-17F基因的A126G、G155A和A161G三个单核苷酸多态性（snp）。我们使用卡方检验或Fisher精确检验比较了双相障碍患者和对照组中IL-17F等位基因、基因型和单倍型的频率。BD患者与对照组IL-17基因A126G SNP等位基因频率和基因型差异有统计学意义（P < 0.001和P < 0.001）。三种IL-17F snp均与BD的多种临床特征无关。单倍型AA的频率在BD患者和对照组之间无差异（P = 0.985）。单倍型AG和GG与BD易感性呈正相关和负相关（P < 0.001和P < 0.001）。这些发现提示IL-17基因snp可能影响双相障碍的易感性。
IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behcet's disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher's exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P < 0.001 and P < 0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P = 0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P < 0.001 and P < 0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.