Iron Achieves Noble Metal Reactivity and Selectivity: Highly Reactive and Enantioselective Iron Complexes as Catalysts in the Hydrosilylation of Ketones
Iron Achieves Noble Metal Reactivity and Selectivity: Highly Reactive and Enantioselective Iron Complexes as Catalysts in the Hydrosilylation of Ketones
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DOI：
10.1021/ja512986m
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发表时间：
2015-02-25
影响因子：
15
通讯作者：
Gade, Lutz H.
中科院分区：
文献类型：
--
作者：
Bleith, Tim;Wadepohl, Hubert;Gade, Lutz H.
手性烷基和含手性四方钳铁的醇铁络合物被用作催化硅氢化反应的催化剂，具有前所未有的活性和选择性(在-40℃下TOF=240h(-1)，对于烷基芳基酮，ee高达99%)，这与以前建立的贵金属催化剂的性能相匹配。这表明，铁等富含地球的金属有潜力取代铂金属，而不会对反应设计造成任何缺陷。
Chiral iron alkyl and iron alkoxide complexes bearing boxmi pincers as stereodirecting ligands have been employed as catalysts for enantioselective hydrosilylation reactions with unprecedented activity and selectivity (TOF = 240 h(-1) at -40 degrees C, ee up to 99% for alkyl aryl ketones), which match the performance of previously established noble-metal-based catalysts. This shows the potential of earth-abundant metals such as iron for replacing platinum-metals without any drawbacks for the reaction design.