Contextually based conditional discrimination of the rabbit eyeblink response.
Contextually based conditional discrimination of the rabbit eyeblink response.
复制标题
基于上下文的兔子眨眼反应的条件辨别。
DOI：
10.1006/nlme.1998.3826
复制
发表时间：
1998
影响因子：
2.7
通讯作者：
Steinmetz,JE
中科院分区：
文献类型：
--
作者：
Rogers,RF;Steinmetz,JE
兔子接受条件辨别训练，使用上下文刺激设置的场合，在眼睑条件反射的刺激配对。具体而言，在整个试验间隔（50 ± 10 s）内，将动物暴露于存在或不存在振荡室光的条件下。对于一半的动物，这种光信号成对呈现的离散音条件刺激（CS）和空气喷吹非条件刺激（US），而黑暗信号的介绍，只有音CS。其余的动物经历了相反的上下文关系的条件刺激。这些试验类型在整个会话中伪随机发生，其中上下文设置之间的所有转换（即，亮或暗）立即发生在CS-US偏移处。在这些条件下，动物成功地利用上下文刺激作为条件线索的差异响应共享CS。此外，光和暗作为辨别性刺激同样有效。动物的一个子集接受进一步的训练，其中通过将所有条件限制为单独的CS上下文来去除上下文偶然性。在没有应急措施的情况下，随后的CS演示（配对和CS单独）在三次训练中诱发了等效的条件反应。恢复后的上下文突发事件，歧视性的反应，立即观察到，并返回到以前的水平在三个会话。最后，动物似乎使用的静态表示的条件线索，而不是线索之间的阶段性过渡，歧视性的反应。这些研究结果进行了讨论，在目前的神经生物学模型的眼睑空调。
Rabbits received conditional discrimination training using contextual stimuli to set the occasion for stimulus pairings during eyelid conditioning. Specifically, animals were exposed to either the presence or the absence of an oscillating chamber light throughout the intertrial interval (50 ± 10 s). For half the animals, this light signaled paired presentations of a discrete tone conditioned stimulus (CS) and air puff unconditioned stimulus (US) while darkness signaled presentations of only the tone CS. The remaining animals experienced the opposite contextual relationship to the conditioning stimuli. These trial types occurred pseudo-randomly across a session, with all transitions between contextual settings (i.e., light or dark) taking place immediately at the CS–US offset. Under these conditions, animals successfully utilized the contextual stimuli as conditional cues for differential responding to the shared CS. Moreover, both light and dark were equally effective as discriminative stimuli. A subset of animals received further training in which the contextual contingency was removed by restricting all conditioning to the CS-alone context. Without the contingency in place, subsequent CS presentations (paired and CS-alone) evoked equivalent conditioned responding across three sessions of training. Following the reinstatement of the contextual contingencies, discriminatory responding was immediately observed and returned to previous levels within three sessions. Finally, animals appeared to use the static representation of the conditional cue, rather than the phasic transition between cues, for discriminatory responding. These findings are discussed in terms of current neurobiological models of eyelid conditioning.