Efficacy of melatonin treatment in jet lag, shift work, and blindness
Efficacy of melatonin treatment in jet lag, shift work, and blindness
复制标题
DOI：
10.1177/074873049701200616
复制
发表时间：
1997-12-01
影响因子：
3.5
通讯作者：
Deacon, S
中科院分区：
文献类型：
--
作者：
Arendt, J;Skene, DJ;Deacon, S
褪黑激素对人类具有计时特性。它能够强烈地改变内源性节律，例如核心温度和其自身的内源性节律，以及睡眠-觉醒周期。它同步自由运行节律的能力尚未在人类身上得到充分研究。有证据表明睡眠-觉醒周期是同步的，但现有数据表明，它对于内源性褪黑激素和核心体温节律的效果较差。大多数研究表明，如果时机适当，速释制剂能够在现场以及时差和轮班工作的模拟研究中加快对相移的适应。主观和客观指标都支持这一说法。然而，并非所有研究都取得了成功。需要仔细评估对工作相关绩效的影响。当用于缓解盲人受试者的非 24 小时睡眠觉醒障碍时，大多数研究报告使用行为测量取得了成功的结果，尽管在少数个体中。然而，目前的数据表明，尽管睡眠-觉醒可以稳定在 24 小时内，但其他节律的夹带却异常罕见。
Melatonin has chronobiotic properties in humans. It is able to phase shift strongly endogenous rhythms, such as core temperature and its own endogenous rhythm, together with the sleep-wake cycle. Its ability to synchronize free-running rhythms has not been fully investigated in humans. There is evidence for synchronization of the sleep-wake cycle, but the available data suggest that it is less effective with regard to endogenous melatonin and core temperature rhythms. When suitably timed, most studies indicate that fast release preparations are able to hasten adaptation to phase shift in both field and simulation studies of jet lag and shift work. Both subjective and objective measures support this statement. However, not all studies have been successful. Careful evaluation of the effects on work-related performance is required. When used to alleviate the non-24-h sleep-wake disorder in blind subjects, again most studies report a successful outcome using behavioral measures, albeit in a small number of individuals. The present data suggest, however, that although sleep-wake can be stabilized to 24 h, entrainment of other rhythms is exceptionally rare.