ESSENTIAL FATTY-ACID DEFICIENCY IN AN INFANT RECEIVING PROLONGED PARENTERAL ALIMENTATION
ESSENTIAL FATTY-ACID DEFICIENCY IN AN INFANT RECEIVING PROLONGED PARENTERAL ALIMENTATION
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DOI：
10.1016/s0022-3476(72)80539-0
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发表时间：
1972-01-01
影响因子：
5.1
通讯作者：
JONSSON, HT
中科院分区：
文献类型：
--
作者：
CALDWELL, MD;OTHERSEN, HB;JONSSON, HT
必需脂肪酸缺乏症，虽然在动物中有很好的记录，但在人类中仅通过严格限制的口服饮食产生。最近，这种缺乏状态的证据已被证明在长期无脂肪肠外营养。本病例报告证实了一例重度必需脂肪酸缺乏症，发生在无脂肠外营养期间，观察到既往在接受口服饮食缺乏必需脂肪酸的婴儿中观察到的鳞状皮肤病变、生长迟缓和血浆脂肪酸模式改变，以及既往在长期接受无脂肠外营养的成人中报告的血小板减少症。在临床上，发现Intradherid可有效纠正仅耐受胃肠外营养的患者的这种缺陷。
Essential fatty acid deficiency, although well documented in animals, has been produced in human beings only through severely restricted oral diets. Recently, evidence for this deficiency state has been demonstrated during prolonged fat-free parenteral alimentation. The present case report demonstrates a case of severe essential fatty acid deficiency which occurred during a period of fat-free parenteral alimentation and in which the scaly skin lesions, growth retardation, and altered plasma fatty acid pattern seen previously in infants receiving oral diets deficient in essential fatty acids were observed as well as the thrombocytopenia previously reported in an adult on prolonged fat-free parenteral nutrition. Intralipid was found to be clinically effective in correcting this deficiency in a patient tolerating only parenteral alimentation.